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L-GLUTAMINE

L-Glutamine or more commonly just called Glutamine is classed as a non-essential amino acid (the body can make it on its own) however the body produces it in insufficient amounts for the needs of a trained athlete. 60% of all skeletal muscle is Glutamine, so it could very well be the most important amino acid for athletes and bodybuilders. Currently we have AMAZING DEALS on Glutamine Tablets !

Glutamine is highly in demand throughout the body. It is used in the gut and immune system extensively to maintain optimal performance. 60% of free-form amino acids floating in skeletal muscles is L-glutamine. L-glutamine plays a very important role in protein metabolism, and it appears to be a very important nutrient for body builders. When supplemented, it may help bodybuilders reduce the amount of muscle deterioration that occurs because other tissues that need glutamine will not rob the glutamine stored in the muscle cells. 

Research shows that after intensely working out, glutamine levels in the body are reduced by as much as 50%. Since the body relies on glutamine as cellular fuel for the immune system, scientific studies have shown that glutamine supplementation can minimize the breakdown of muscle tissue and improve protein metabolism. Its effects on replenishing the body after stress or trauma have been shown in Europe where it is commonly given to patients in hospitals. Glutamine's cell-volumizing effects have also been shown in several studies. No conclusive studies have been done to evaluate the effects of L-glutamine supplementation on weight-training adults; however, a recent study showed up to a 400% increase in growth-hormone levels when as little as 2 grams of free-form L-glutamine supplement was consumed!

150 x MAX POTENCY GLUTAMINE CAPSULES ORDER NOW only £ 

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Use L-Glutamine to:

  • Accelerate Muscle Growth
  • Repair muscle tissue FASTER
  • Prevents post workout muscle tissue breakdown
  • Enhances and Speeds up post workout recovery
  • Increases natural growth hormone + lower levels of fat
  • Improve cell-volumisation - meaning fuller, harder muscle tone
  • Enhance strength and sporting performance
     

Glutamine is the most abundant free-form amino acid in muscle, comprising over 50% of the free amino acids.

During and after intense training, large amounts of glutamine are released from muscle. The deficit created by this triggers the conversion of other amino acids into glutamine, which is a catabolic (muscle wasting) action. Oral supplementation of L-Glutamine helps to prevent muscle wastage caused by this natural recovery process.

 

150 x MAX POTENCY GLUTAMINE CAPSULES ORDER NOW only £ 

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Glutamine has become increasingly popular as new studies reveal its unique contribution to protein synthesis, muscle growth, anti-catabolic (preventing muscle tissue breakdown) and growth hormone elevating effects.

Glutamine concentrations falls sharply after training within as little as 30 minutes, and remains low until complete recovery, up to as long as 5 – 7 days, resulting in decreases in strength, stamina and recovery. It is therefore critical for maintaining and building muscle tissue. The higher the muscle glutamine levels you can maintain, the less chance you have of falling into catabolism and the faster muscle will recover and grow.

Normally to get the correct dosage you have to take LOTS of Hard to Swallow Pills - now however you can get HARDCORE MAX POTENCY GLUTAMINE CHEWIES!

HARDCORE - Pro Series Bodybuilding Supplement for MAXIMUM GROWTH


What Are Branched-Chain Amino Acids?
The BCAA Are A Group Of Three Essential Amino Acids:

1. Leucine
2. Isoleucine
3. Valine

The BCAA are different from the other 17 amino acids in that they are primarily metabolized in skeletal muscle (Layman, 2003) and metabolized ata much lower rate in the liver (Norton, 2005). The rate limiting enzyme in BCAA catabolism is Branched Chain Keto Acid Dehydrogenase, which is much more active in skeletal muscle than in the liver (Norton, 2005).
Point blank, exercise promotes increased BCAA oxidation (Shirmomura et al., 2004). This increased degradation of BCAA helps maintain energy homeostasis by providing carbon as a direct energy source and glucose homeostasis by providing substrates for the citric-acid cycle and gluconeogenesis.

Amino acids are categorized as glucogenic, ketogenic, or a combination of glucogenic and ketogenic. A glucogenic amino acid when metabolized gives rise to pyruvate or other TCA cycle intermediates that can be used for the production of glucose through gluconeogenesis.

A ketogenic amino acid is metabolized via the fatty acid pathway and gives rise to actyl-CoA, a fatty acid precursor. Leucine is completely ketogenic, valine is completely glucogenic, and isoleucine is both glucogenic and ketogenic. Valine and isoleucine can both be used to produce intermediates for glucose production via gluconeogenesis.

Due to leucine's metabolic properties (discussed below), increasing attention is being given to it and its metabolism. Research has shown plasma leucine levels to decrease during both aerobic and anaerobic exercise (Mero, 1999).

According to Freund and Hanani (2002), "Complete oxidation of leucine in the muscle yields more adenosine triphosphate molecules on a molar basis than complete oxidation of glucose." So leucine can provide skeletal muscle with more ATP than an equal amount of glucose, which is due to leucine being completely ketogenic and metabolized via the fatty acid pathway.

In order to meet the increased demand for BCAA during exercise the body breaks down muscle tissue to supply additional BCAA. By supplying the body exogenous BCAA during exercise, one can  meet the increased demand for BCAA oxidation without breaking down muscle tissue to supply the needed BCAA.

Because BCAA serve as a "fuel" for skeletal muscle, supplementing with additional BCAA during your workout improves your performance without the added calories or insulin spike (which can lead to fat storage) caused by carbohydrates.

Leucine Stimulates Leptin Expression through mTOR activation in Adipocytes

Intake of leucine stimulates expression of the hormone leptin in adipocytes (the primary site of leptin secretion) through activation of the mTOR pathway (Meijer and Dubbelhuis, 2003). Leptin is a very complicated hormone; the gist of it is involved in the regulation of metabolism, body weight, and appetite.

Leptin secretion is linked with body fat levels; higher body fat is associated with higher leptin secretion and lower body fat is associated with lower leptin levels. When you diet and lose fat, the amount of leptin you secrete decreases, which makes your body "crave" food in an attempt to bring your body fat level back up to where the body is comfortable (known as the body fat "set point").

Leucine has the ability to activate leptin expression and will cause the body to think it is "fed" or receiving "adequate" calories, which will keep things running (specifically your metabolism) smoothly.

BCAA and the Glucose-Alanine Cycle

The BCAA's are involved in maintaining glucose homeostasis through the glucose-alanine cycle (see figure 1). The glucose-alanine cycle involves pyruvate (derived from glucose/glycogen) being transaminated in muscle to form alanine, with the BCAA serving as the main nitrogen source (donors) for the synthesis of alanine (Holecek, 2002).

The newly synthesized alanine is released in the blood stream and sent to the liver where it is converted into glucose through gluconeogenesis. This glucose can then be sent from the liver back to the working muscle to be used as fuel. Supplementing with BCAA allowing your body to create glucose to use for fuel without the added calories or insulin spike (which can lead to fat storage) caused by carbohydrates.

L-Glutamine

Glutamine is a glucogenic (glucose creating), nonessential amino acid that has multiple roles in the body. Glutamine is synthesized mainly in skeletal muscle and the liver and acts as a "nitrogen shuttle" between organs, a fuel for cells of the immune system and intestines, and a precursor for nucleotide synthesis (Holecek, 2002).

Glutamine is also a powerful cell volumizer (Haussinger et al. 1993). An increase in cell volume, also called cell swelling, stimulates anabolic pathways (synthesis of proteins and glycogen) and inhibits catabolic pathways (protein degradation) (Haussinger, 1993).

According to Houston (2001), "Glutamine content in skeletal muscle and other tissues appears to have a regulatory role in whole body protein synthesis." Glutamine levels inside muscle govern protein synthesis and nitrogen balance and therefore muscle growth (VanAcker et al. 1999).

Adequate glutamine concentrations are needed for optimal health and skeletal muscle hypertrophy. Therefore one would want to keep glutamine levels elevated, especially during/post exercise.

Glutamine Metabolism and Exercise

During times of stress, such as exercise, skeletal muscle glutamine levels are depleted. This glutamine released from skeletal muscle is derived from muscle proteins, the intramuscular free aminoMarika LOVES XTEND!!! acid pool, and newly synthesized glutamine (VanAcker, 1999). The newly synthesized glutamine is created by using BCAAs obtained from muscle protein breakdown (Holecek, 2002).

Plasma and muscle glutamine levels are decreased post workout and it can take hours before they are restored (Rowbottom, 1996). A study examining the effect of free-form glutamine and glutamine peptide ingestion on muscle glycogen resynthesis found that plasma glutamine was decreased by 20% post workout with the ingestion of glucose only (control), showed no change with ingestion of whey protein or wheat protein hydrolysate plus glucose drinks, and a 200% increase with ingestion of free-form glutamine plus glucose drink (VanHall, 2000). Free-form glutamine supplementation was needed to elevate plasma glutamine levels post workout.

In addition to restoring and elevating plasma glutamine levels, oral glutamine supplementation increases muscle glycogen storage to the same capacity as glucose (Bowtell, 1999). Glutamine can replenish glycogen levels without the added calories or insulin spike (which can lead to fat storage) caused by carbohydrates.

Mammalian Target of Rapamycin (mTOR)

The Mammalian Target of Rapamycin (mTOR) is one of the body's protein synthesis regulators. mTOR functions as an energy sensor; it is activated when ATP levels are high and blocked when ATP levels are decreased (AMPK is activated when ATP decreases, which works antagonistically to mTOR).

The main energy-consuming process in the cell is protein synthesis. When mTOR is activated (high ATP levels sensed) protein synthesis is increased and when mTOR is suppressed (low ATP levels are sensed) protein synthesis is blunted.

MTOR activation is vital for skeletal muscle hypertrophy. Interestingly, mTOR is also a nutrient sensor of amino acid availability, specifically of leucine availability. Research has shown that regulation of mTOR by ATP and amino acids act independently through separate mechanisms (Dennis et al., 2001).




 



 

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